SOPHiA GENETICS SA
SOPHNASDAQUSD
- Source valuation snapshot. Not a live recalculation.
- Latest filed annual earnings; price snapshot date unavailable. Not forward P/E.
- Diluted earnings per share from the latest filed annual.
- $7.86 Prior regular-session close from the quote source.
- $7.42–$7.98 Regular-session low and high so far today.
- 837.9K Regular-session shares traded · Nov 11, 4:00 PM ET.
- Not yet confirmed The company has not confirmed its next report date. Reported quarters are available in the chart’s Earnings view.
- $3.83–$8.98 52-week trading low and high returned by the quote source.
Understand the Business
Why the Stock Moved
Period-matched expectations history is not yet available. Current metrics are not a substitute for a historical explanation.
The core investment thesis
Own SOPH if its cloud genomics and clinical-data analytics platform scales into a high-gross-margin, self-funding workflow layer before competition or cash burn forces dilution.
SOPH price history
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Investment thesis
What must happen next
Hospitals and laboratories keep choosing SOPHiA’s external cloud analytics platform over building in-house genomic interpretation pipelines, so growing clinical sequencing demand continues to convert into paid platform usage.StrengtheningMateriality: High
IFRS annual revenue increased from $47.6 million in FY2022 to $77.3 million in FY2025. If this holds, SOPH has a real adoption engine; if it breaks, revenue growth becomes a temporary customer-acquisition artifact rather than evidence of product-market fit.
Watch: Illumina, QIAGEN, DNAnexus, Fabric Genomics, Tempus, or other better-funded genomics platforms win hospital and lab workflows by bundling interpretation with sequencing, assays, or clinical reporting.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
IFRS annual revenue increased from $47.6 million in FY2022 to $77.3 million in FY2025.
Open source ↗SOPHiA’s analytics model retains enough pricing power and compute efficiency that incremental platform usage does not get competed down into low-margin services economics.StrengtheningMateriality: High
IFRS annual gross profit rose from $31.3 million in FY2022 to $52.1 million in FY2025. Durable gross margin is the bridge from adoption to enterprise value; if pricing or compute costs deteriorate, growth can destroy cash rather than create it.
Watch: Sequencing-instrument vendors or clinical-lab software competitors bundle interpretation tools at low or no incremental price.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
IFRS annual gross profit rose from $31.3 million in FY2022 to $52.1 million in FY2025.
Open source ↗The fixed R&D, regulatory, and commercial cost base must begin to scale more slowly than platform revenue; otherwise SOPHiA is a high-gross-margin product without a profitable operating model.HoldingMateriality: Medium
IFRS annual operating loss improved from negative $87.8 million in FY2022 to negative $70.9 million in FY2025. This is the difference between a valuable platform and a perpetually cash-consuming healthtech company.
Watch: New customer deployments continue to require heavy bespoke integration, clinical validation, and support rather than repeatable platform onboarding.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
IFRS annual operating loss improved from negative $87.8 million in FY2022 to negative $70.9 million in FY2025.
Open source ↗Management’s cost discipline and platform scaling reduce operating cash burn fast enough to avoid a financing-driven reset in per-share value.HoldingMateriality: Medium
IFRS annual operating cash flow improved from negative $70.1 million in FY2022 to negative $35.9 million in FY2025. Even if the product wins customers, owners can lose if the company must raise capital on unfavorable terms before reaching self-funding.
Watch: Hospital procurement cycles lengthen or reimbursement pressure slows customer expansion, delaying cash conversion while fixed costs remain.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
IFRS annual operating cash flow improved from negative $70.1 million in FY2022 to negative $35.9 million in FY2025.
Open source ↗
Full investment case & evidence
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Original research
Hospitals and laboratories keep choosing SOPHiA’s external cloud analytics platform over building in-house genomic interpretation pipelines, so growing clinical sequencing demand continues to convert into paid platform usage. If this holds, SOPH has a real adoption engine; if it breaks, revenue growth becomes a temporary customer-acquisition artifact rather than evidence of product-market fit.
SOPHiA’s analytics model retains enough pricing power and compute efficiency that incremental platform usage does not get competed down into low-margin services economics. Durable gross margin is the bridge from adoption to enterprise value; if pricing or compute costs deteriorate, growth can destroy cash rather than create it.
The fixed R&D, regulatory, and commercial cost base must begin to scale more slowly than platform revenue; otherwise SOPHiA is a high-gross-margin product without a profitable operating model. This is the difference between a valuable platform and a perpetually cash-consuming healthtech company.
Management’s cost discipline and platform scaling reduce operating cash burn fast enough to avoid a financing-driven reset in per-share value. Even if the product wins customers, owners can lose if the company must raise capital on unfavorable terms before reaching self-funding.
All standing thesis claims
Original report summary
its cloud genomics and clinical-data analytics platform scales into a high-gross-margin, self-funding workflow layer before competition or cash burn forces dilution.
Bull case and bear case
Bull case and bear case for SOPHiA GENETICS SA
Where the evidence on SOPHiA GENETICS SA stands: Holding on the latest evidence (Nov 12, 2026). Of its 4 thesis points, 2 strengthening and 2 holding.
Bull case: what the evidence supports
Hospitals and laboratories keep choosing SOPHiA’s external cloud analytics platform over building in-house genomic interpretation pipelines, so growing clinical sequencing demand continues to convert into paid platform usage.
SOPHiA’s analytics model retains enough pricing power and compute efficiency that incremental platform usage does not get competed down into low-margin services economics.
The fixed R&D, regulatory, and commercial cost base must begin to scale more slowly than platform revenue; otherwise SOPHiA is a high-gross-margin product without a profitable operating model.
Management’s cost discipline and platform scaling reduce operating cash burn fast enough to avoid a financing-driven reset in per-share value.
Bear case: what would count against it
Illumina, QIAGEN, DNAnexus, Fabric Genomics, Tempus, or other better-funded genomics platforms win hospital and lab workflows by bundling interpretation with sequencing, assays, or clinical reporting.
Sequencing-instrument vendors or clinical-lab software competitors bundle interpretation tools at low or no incremental price.
New customer deployments continue to require heavy bespoke integration, clinical validation, and support rather than repeatable platform onboarding.
Thesis-Break Engine
Thesis-break watch · SOPHiA GENETICS SA
Loading the break-condition record for SOPHiA GENETICS SA.
MARKET + FINANCIAL SNAPSHOT
The numbers behind the thesis
What Changed
- MixedForeign issuer material report (6-K).
SOPHiA GENETICS SA filed an SEC report on 2026-11-03: Foreign issuer material report (6-K). It is a dated development that tests the current thesis.
- MixedForeign issuer material report (6-K).
SOPHiA GENETICS SA filed an SEC report on 2026-08-04: Foreign issuer material report (6-K). It is a dated development that tests the current thesis.
- MixedForeign issuer material report (6-K).
SOPHiA GENETICS SA filed an SEC report on 2026-06-22: Foreign issuer material report (6-K). It is a dated development that tests the current thesis.
Risks / falsifiers
What could break the thesis
- Illumina, QIAGEN, DNAnexus, Fabric Genomics, Tempus, or other better-funded genomics platforms win hospital and lab workflows by bundling interpretation with sequencing, assays, or clinical reporting.
- Sequencing-instrument vendors or clinical-lab software competitors bundle interpretation tools at low or no incremental price.
- New customer deployments continue to require heavy bespoke integration, clinical validation, and support rather than repeatable platform onboarding.
- Hospital procurement cycles lengthen or reimbursement pressure slows customer expansion, delaying cash conversion while fixed costs remain.
SOPH news
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Financial statements
SOPH income statement
Annual filed results · USD · Oldest to newest. Margins are calculated from the reported figures.
SOPH: quick answers
- What is SOPH's short interest?
- As of October 30, 2026, 1.1M SOPH shares were sold short, up 14.8% from the count before. At the stock's average daily volume that is 2.6 days to cover. FINRA publishes the count twice a month. SOPH short interest history
- Which well-known investors own SOPH?
- 1 of the 37 well-known funds tracked here reported SOPH shares in their latest 13F filing. By share of the fund's portfolio: Akre Capital Management (Chuck Akre), 0.4%. Fund portfolios
SOPH in well-known investors’ portfolios
1 of 37 funds reported SOPH shares in their latest 13F filing. A 13F shows quarter-end positions and arrives up to 45 days later.
| Fund | Of its portfolio | Value | Change | Quarter |
|---|---|---|---|---|
| Chuck AkreAkre Capital Management | 0.42% | $21.5M | No change | Q2 2026 |
