SOPHiA GENETICS SA

SOPHNASDAQUSD

THESIS ALERT

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$7.47
−$0.40 (−5.03%)Today 1M +6.07%
After hours$7.470.00%

Updated Nov 11, 4:00 PM ET · Regular session · May be delayed

Source valuation snapshot. Not a live recalculation.
Latest filed annual earnings; price snapshot date unavailable. Not forward P/E.
Diluted earnings per share from the latest filed annual.
$7.86
Prior regular-session close from the quote source.
$7.42–$7.98
Regular-session low and high so far today.
837.9K
Regular-session shares traded · Nov 11, 4:00 PM ET.
Not yet confirmed
The company has not confirmed its next report date. Reported quarters are available in the chart’s Earnings view.
$3.83–$8.98
52-week trading low and high returned by the quote source.

Understand the Business

Why the Stock Moved

Period-matched expectations history is not yet available. Current metrics are not a substitute for a historical explanation.

The core investment thesis

Own SOPH if its cloud genomics and clinical-data analytics platform scales into a high-gross-margin, self-funding workflow layer before competition or cash burn forces dilution.

SOPH price history

Latest price$7.46Today−$0.40 (-5.03%)
SOPH +2.26%S&P 500 -2.42%Since first plotted close
4 hours

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Investment thesis

What must happen next

4 MATERIAL PROPOSITIONS
  • Hospitals and laboratories keep choosing SOPHiA’s external cloud analytics platform over building in-house genomic interpretation pipelines, so growing clinical sequencing demand continues to convert into paid platform usage.StrengtheningMateriality: High

    IFRS annual revenue increased from $47.6 million in FY2022 to $77.3 million in FY2025. If this holds, SOPH has a real adoption engine; if it breaks, revenue growth becomes a temporary customer-acquisition artifact rather than evidence of product-market fit.

    Watch: Illumina, QIAGEN, DNAnexus, Fabric Genomics, Tempus, or other better-funded genomics platforms win hospital and lab workflows by bundling interpretation with sequencing, assays, or clinical reporting.

    Supporting sources

    Source notes are factual paraphrases; read the original disclosures below.

    IFRS annual revenue increased from $47.6 million in FY2022 to $77.3 million in FY2025.

    Open source ↗
  • SOPHiA’s analytics model retains enough pricing power and compute efficiency that incremental platform usage does not get competed down into low-margin services economics.StrengtheningMateriality: High

    IFRS annual gross profit rose from $31.3 million in FY2022 to $52.1 million in FY2025. Durable gross margin is the bridge from adoption to enterprise value; if pricing or compute costs deteriorate, growth can destroy cash rather than create it.

    Watch: Sequencing-instrument vendors or clinical-lab software competitors bundle interpretation tools at low or no incremental price.

    Supporting sources

    Source notes are factual paraphrases; read the original disclosures below.

    IFRS annual gross profit rose from $31.3 million in FY2022 to $52.1 million in FY2025.

    Open source ↗
  • The fixed R&D, regulatory, and commercial cost base must begin to scale more slowly than platform revenue; otherwise SOPHiA is a high-gross-margin product without a profitable operating model.HoldingMateriality: Medium

    IFRS annual operating loss improved from negative $87.8 million in FY2022 to negative $70.9 million in FY2025. This is the difference between a valuable platform and a perpetually cash-consuming healthtech company.

    Watch: New customer deployments continue to require heavy bespoke integration, clinical validation, and support rather than repeatable platform onboarding.

    Supporting sources

    Source notes are factual paraphrases; read the original disclosures below.

    IFRS annual operating loss improved from negative $87.8 million in FY2022 to negative $70.9 million in FY2025.

    Open source ↗
  • Management’s cost discipline and platform scaling reduce operating cash burn fast enough to avoid a financing-driven reset in per-share value.HoldingMateriality: Medium

    IFRS annual operating cash flow improved from negative $70.1 million in FY2022 to negative $35.9 million in FY2025. Even if the product wins customers, owners can lose if the company must raise capital on unfavorable terms before reaching self-funding.

    Watch: Hospital procurement cycles lengthen or reimbursement pressure slows customer expansion, delaying cash conversion while fixed costs remain.

    Supporting sources

    Source notes are factual paraphrases; read the original disclosures below.

    IFRS annual operating cash flow improved from negative $70.1 million in FY2022 to negative $35.9 million in FY2025.

    Open source ↗
Full investment case & evidence

Loading the original research archive…

Original research

Hospitals and laboratories keep choosing SOPHiA’s external cloud analytics platform over building in-house genomic interpretation pipelines, so growing clinical sequencing demand continues to convert into paid platform usage. If this holds, SOPH has a real adoption engine; if it breaks, revenue growth becomes a temporary customer-acquisition artifact rather than evidence of product-market fit.

SOPHiA’s analytics model retains enough pricing power and compute efficiency that incremental platform usage does not get competed down into low-margin services economics. Durable gross margin is the bridge from adoption to enterprise value; if pricing or compute costs deteriorate, growth can destroy cash rather than create it.

The fixed R&D, regulatory, and commercial cost base must begin to scale more slowly than platform revenue; otherwise SOPHiA is a high-gross-margin product without a profitable operating model. This is the difference between a valuable platform and a perpetually cash-consuming healthtech company.

Management’s cost discipline and platform scaling reduce operating cash burn fast enough to avoid a financing-driven reset in per-share value. Even if the product wins customers, owners can lose if the company must raise capital on unfavorable terms before reaching self-funding.

All standing thesis claims
Original report summary

its cloud genomics and clinical-data analytics platform scales into a high-gross-margin, self-funding workflow layer before competition or cash burn forces dilution.

Evidence assessed Nov 12, 2026. Expand each conclusion for its evidence and what would change it. Thesis evidence—not a buy or sell recommendation.

Bull case and bear case

Bull case and bear case for SOPHiA GENETICS SA

Where the evidence on SOPHiA GENETICS SA stands: Holding on the latest evidence (Nov 12, 2026). Of its 4 thesis points, 2 strengthening and 2 holding.

Bull case: what the evidence supports

  • Hospitals and laboratories keep choosing SOPHiA’s external cloud analytics platform over building in-house genomic interpretation pipelines, so growing clinical sequencing demand continues to convert into paid platform usage.

    sec.gov ↗

  • SOPHiA’s analytics model retains enough pricing power and compute efficiency that incremental platform usage does not get competed down into low-margin services economics.

    sec.gov ↗

  • The fixed R&D, regulatory, and commercial cost base must begin to scale more slowly than platform revenue; otherwise SOPHiA is a high-gross-margin product without a profitable operating model.

    sec.gov ↗

  • Management’s cost discipline and platform scaling reduce operating cash burn fast enough to avoid a financing-driven reset in per-share value.

    sec.gov ↗

Bear case: what would count against it

  • Illumina, QIAGEN, DNAnexus, Fabric Genomics, Tempus, or other better-funded genomics platforms win hospital and lab workflows by bundling interpretation with sequencing, assays, or clinical reporting.

    sec.gov ↗

  • Sequencing-instrument vendors or clinical-lab software competitors bundle interpretation tools at low or no incremental price.

    sec.gov ↗

  • New customer deployments continue to require heavy bespoke integration, clinical validation, and support rather than repeatable platform onboarding.

    sec.gov ↗

Thesis-Break Engine

Thesis-break watch · SOPHiA GENETICS SA

12 mo agonow
Trailing daily price. No thesis break has crossed here, so there is no break base rate to project.

Loading the break-condition record for SOPHiA GENETICS SA.

How the Thesis-Break Engine works →Historical outcomes are measured against the market after past breaks of the same kind, across all companies. Not a prediction.

MARKET + FINANCIAL SNAPSHOT

The numbers behind the thesis

Sourced from filings and market data

What Changed

  1. Mixed
    Foreign issuer material report (6-K).

    SOPHiA GENETICS SA filed an SEC report on 2026-11-03: Foreign issuer material report (6-K). It is a dated development that tests the current thesis.

  2. Mixed
    Foreign issuer material report (6-K).

    SOPHiA GENETICS SA filed an SEC report on 2026-08-04: Foreign issuer material report (6-K). It is a dated development that tests the current thesis.

  3. Mixed
    Foreign issuer material report (6-K).

    SOPHiA GENETICS SA filed an SEC report on 2026-06-22: Foreign issuer material report (6-K). It is a dated development that tests the current thesis.

Risks / falsifiers

What could break the thesis

  • Illumina, QIAGEN, DNAnexus, Fabric Genomics, Tempus, or other better-funded genomics platforms win hospital and lab workflows by bundling interpretation with sequencing, assays, or clinical reporting.
  • Sequencing-instrument vendors or clinical-lab software competitors bundle interpretation tools at low or no incremental price.
  • New customer deployments continue to require heavy bespoke integration, clinical validation, and support rather than repeatable platform onboarding.
  • Hospital procurement cycles lengthen or reimbursement pressure slows customer expansion, delaying cash conversion while fixed costs remain.

SOPH news

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Financial statements

SOPH income statement

Annual filed results · USD · Oldest to newest. Margins are calculated from the reported figures.

SOPH: quick answers

What is SOPH's short interest?
As of October 30, 2026, 1.1M SOPH shares were sold short, up 14.8% from the count before. At the stock's average daily volume that is 2.6 days to cover. FINRA publishes the count twice a month. SOPH short interest history
Which well-known investors own SOPH?
1 of the 37 well-known funds tracked here reported SOPH shares in their latest 13F filing. By share of the fund's portfolio: Akre Capital Management (Chuck Akre), 0.4%. Fund portfolios

SOPH in well-known investors’ portfolios

1 of 37 funds reported SOPH shares in their latest 13F filing. A 13F shows quarter-end positions and arrives up to 45 days later.

FundOf its portfolioValueChangeQuarter
Chuck AkreAkre Capital Management0.42%$21.5MNo changeQ2 2026

Every fund’s portfolio

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