Senti Biosciences Holdings
SNTINASDAQUSD
- — Source valuation snapshot. Not a live recalculation.
- — Latest filed annual earnings; price snapshot date unavailable. Not forward P/E.
- — Diluted earnings per share from the latest filed annual.
- $0.14 Prior regular-session close from the quote source.
- $0.14–$0.16 Regular-session low and high so far today.
- 115.4K Regular-session shares traded · Nov 11, 12:47 PM ET.
- Nov 12 projected Projected for 2026-11-12 from the company’s own results filings (SEC 8-K Item 2.02). The company has not confirmed the date.
- $0.14–$2.88 52-week trading low and high returned by the quote source.
Understand the Business
Why the Stock Moved
Period-matched expectations history is not yet available. Current metrics are not a substitute for a historical explanation.
The core investment thesis
Own SNTI if Senti is a high-risk biotech option whose value depends less on current operations than on whether its biology platform can attract credible clinical or partner validation before the balance sheet forces punitive financing.
SNTI price history
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INVESTMENT THESIS
What must happen next
Senti is capital-access constrained, so the platform can only keep advancing if investors or strategic partners remain willing to fund development before liquidity dictates the strategy.WeakeningMateriality: High
GAAP cash and cash equivalents were $16.4 million at FY2025 year-end, down from $48.3 million at FY2024 year-end. If funding arrives on acceptable terms, current holders retain option value; if not, dilution, restructuring, or wind-down risk can overwhelm any scientific promise.
Watch: A strategic collaboration with meaningful upfront cash would extend runway and validate the platform.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
GAAP cash and cash equivalents were $16.4 million at FY2025 year-end, down from $48.3 million at FY2024 year-end.
Open source ↗Senti has not yet proven recurring customer or partner demand, so value creation must come from future scientific validation rather than existing commercial traction.StrengtheningMateriality: High
FY2025 annual GAAP revenue was only $22 thousand. The stock’s upside is event-driven; absent validation, there is no recurring revenue base to absorb R&D losses.
Watch: A large pharmaceutical or biotechnology partner signs a platform collaboration with upfront payments.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
FY2025 annual GAAP revenue was only $22 thousand.
Open source ↗Management must keep R&D and overhead burn within a financeable envelope; otherwise even promising science will accrue mainly to new capital providers rather than current shareholders.HoldingMateriality: Medium
FY2025 annual GAAP operating cash flow was negative $43.4 million, compared with negative $41.4 million in FY2024 and negative $52.4 million in FY2023. For a pre-commercial biotech, per-share value depends on how much ownership must be sold before proof points arrive.
Watch: Trial expansion, manufacturing scale-up, or external development commitments cause cash burn to step up before financing is secured.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
FY2025 annual GAAP operating cash flow was negative $43.4 million, compared with negative $41.4 million in FY2024 and negative $52.4.
Open source ↗Balance-sheet weakness gives future capital providers increasing bargaining power, so preserving per-share value requires non-punitive financing or strategic validation rather than rescue capital.StrengtheningMateriality: Medium
GAAP stockholders’ equity declined to $5.6 million at FY2025 year-end from $25.6 million at FY2024 year-end and $66.9 million at FY2023 year-end. The same enterprise outcome can be good or bad for current holders depending on how much dilution or creditor preference is required to reach it.
Watch: A non-dilutive partnership or licensing deal replenishes the balance sheet before emergency financing is needed.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
GAAP stockholders’ equity declined to $5.6 million at FY2025 year-end from $25.6 million at FY2024 year-end and $66.9 million at.
Open source ↗Senti’s operating losses are value-building only if they produce decision-changing clinical, regulatory, or partnership proof; without those proof points, the spend is option decay.HoldingMateriality: Medium
FY2025 annual GAAP operating income was negative $68.8 million. A holder needs evidence that losses are buying a higher-probability asset, not merely consuming runway.
Watch: A clinical readout, regulatory clearance, or development milestone materially increases the probability that the platform can become a partnered or commercial asset.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
FY2025 annual GAAP operating income was negative $68.8 million.
Open source ↗
Full investment case & evidence
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Original research
Senti is capital-access constrained, so the platform can only keep advancing if investors or strategic partners remain willing to fund development before liquidity dictates the strategy. If funding arrives on acceptable terms, current holders retain option value; if not, dilution, restructuring, or wind-down risk can overwhelm any scientific promise.
Senti has not yet proven recurring customer or partner demand, so value creation must come from future scientific validation rather than existing commercial traction. The stock’s upside is event-driven; absent validation, there is no recurring revenue base to absorb R&D losses.
Management must keep R&D and overhead burn within a financeable envelope; otherwise even promising science will accrue mainly to new capital providers rather than current shareholders. For a pre-commercial biotech, per-share value depends on how much ownership must be sold before proof points arrive.
Balance-sheet weakness gives future capital providers increasing bargaining power, so preserving per-share value requires non-punitive financing or strategic validation rather than rescue capital. The same enterprise outcome can be good or bad for current holders depending on how much dilution or creditor preference is required to reach it.
Senti’s operating losses are value-building only if they produce decision-changing clinical, regulatory, or partnership proof; without those proof points, the spend is option decay. A holder needs evidence that losses are buying a higher-probability asset, not merely consuming runway.
All standing thesis claims
Original report summary
Senti is a high-risk biotech option whose value depends less on current operations than on whether its biology platform can attract credible clinical or partner validation before the balance sheet forces punitive financing.
BULL CASE / BEAR CASE
Bull case and bear case for Senti Biosciences Holdings
Where the evidence on Senti Biosciences Holdings disagrees: Mixed on the latest evidence (Oct 12, 2026). Of its 5 thesis points, 2 strengthening, 2 holding and 1 weakening.
Bull case: what the evidence supports
Senti has not yet proven recurring customer or partner demand, so value creation must come from future scientific validation rather than existing commercial traction.
Management must keep R&D and overhead burn within a financeable envelope; otherwise even promising science will accrue mainly to new capital providers rather than current shareholders.
Balance-sheet weakness gives future capital providers increasing bargaining power, so preserving per-share value requires non-punitive financing or strategic validation rather than rescue capital.
Senti’s operating losses are value-building only if they produce decision-changing clinical, regulatory, or partnership proof; without those proof points, the spend is option decay.
Bear case: what the evidence questions
Senti is capital-access constrained, so the platform can only keep advancing if investors or strategic partners remain willing to fund development before liquidity dictates the strategy.
Thesis-Break Engine
Thesis-break watch · Senti Biosciences Holdings
No break has crossed Senti Biosciences Holdings’s thesis. Its break conditions are checked against every new filing as it lands.
MARKET + FINANCIAL SNAPSHOT
The numbers behind the thesis
What Changed
- MIXEDDirector or principal officer change.
Senti Biosciences Holdings filed an SEC 8-K on 2026-09-24: Director or principal officer change. It is a dated development that tests the current thesis.
- MIXEDEntered a material definitive agreement.
Senti Biosciences Holdings filed an SEC 8-K on 2026-09-04: Entered a material definitive agreement. It is a dated development that tests the current thesis.
- MIXEDDelisting notice or listing-rule failure.
Senti Biosciences Holdings filed an SEC 8-K on 2026-09-02: Delisting notice or listing-rule failure. It is a dated development that tests the current thesis.
RISKS / FALSIFIERS
What could break the thesis
- A strategic collaboration with meaningful upfront cash would extend runway and validate the platform.
- A large pharmaceutical or biotechnology partner signs a platform collaboration with upfront payments.
- Trial expansion, manufacturing scale-up, or external development commitments cause cash burn to step up before financing is secured.
- A non-dilutive partnership or licensing deal replenishes the balance sheet before emergency financing is needed.
- A clinical readout, regulatory clearance, or development milestone materially increases the probability that the platform can become a partnered or commercial asset.
SNTI news
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FINANCIAL STATEMENTS
SNTI income statement
Annual filed results · USD · Oldest to newest. Margins are calculated from the reported figures.
SNTI: quick answers
- When does Senti Biosciences Holdings (SNTI) report earnings next?
- Senti Biosciences Holdings's next results are projected for November 12, 2026, from the dates of its own results filings with the SEC. The company has not confirmed the date. It last reported on July 15, 2026. Earnings calendar
- What is SNTI's short interest?
- As of October 30, 2026, 1.1M SNTI shares were sold short, up 160.9% from the count before. At the stock's average daily volume that is 1.0 day to cover. FINRA publishes the count twice a month. SNTI short interest history
