Cryoport
CYRXNASDAQUSD
- Source valuation snapshot. Not a live recalculation.
- Latest filed annual earnings; price snapshot date unavailable. Not forward P/E.
- Diluted earnings per share from the latest filed annual.
- $20.74 Prior regular-session close from the quote source.
- $20.47–$21.78 Regular-session low and high so far today.
- 943.6K Regular-session shares traded · Nov 11, 4:00 PM ET.
- Mar 2 projected Projected for 2027-03-02 from the company’s own results filings (SEC 8-K Item 2.02). The company has not confirmed the date.
- $7.61–$21.78 52-week trading low and high returned by the quote source.
Understand the Business
Why the Stock Moved
Period-matched expectations history is not yet available. Current metrics are not a substitute for a historical explanation.
The core investment thesis
Own CYRX if Cryoport is a leveraged bet that specialized cell-and-gene-therapy cold-chain logistics becomes unavoidable infrastructure and scales faster than fixed network costs and competition commoditize it.
CYRX price history
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Investment thesis
What must happen next
CGT sponsors and life-sciences customers continue choosing Cryoport for mission-critical temperature-controlled workflows because the cost of a handling failure outweighs the cost of a specialized provider.HoldingMateriality: High
The company describes itself as a leading global provider of integrated, temperature-controlled supply chain solutions for life sciences, with a strong focus on the rapidly growing CGT market. If Cryoport stays embedded in clinical and commercial therapy logistics, revenue can recover; if customers redesign workflows around other providers or in-house systems, the growth thesis breaks before the income statement fully shows it.
Watch: Large CGT sponsors standardize pivotal or commercial distribution with UPS Healthcare, World Courier/Cencora, DHL Life Sciences, or Marken instead of Cryoport.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
The company describes itself as a leading global provider of integrated, temperature-controlled supply chain solutions for life sciences, with a.
Open source ↗Cryoport’s regulatory, cryogenic, and chain-of-custody requirements give it enough differentiation to avoid pure price competition in life-sciences logistics.StrengtheningMateriality: High
GAAP annual gross profit rose from $69.7 million in FY2024 to $83.1 million in FY2025. If specialization protects pricing, incremental revenue has a chance to create value; if the service is commoditized, revenue growth would be low-quality and margin-dilutive.
Watch: UPS Healthcare, DHL, World Courier/Cencora, or Marken match Cryoport’s CGT-specific service quality while undercutting price.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
GAAP annual gross profit rose from $69.7 million in FY2024 to $83.1 million in FY2025.
Open source ↗Cryoport’s integrated global platform becomes economically attractive only if recovered CGT and life-sciences volume absorbs fixed network, compliance, and personnel costs.HoldingMateriality: Medium
GAAP annual operating loss improved from $121.7 million in FY2024 to $36.8 million in FY2025. The equity upside depends on moving from a specialized service with good gross profit to a business that earns positive operating income; if scale does not arrive, the model remains structurally unprofitable.
Watch: CGT commercial volumes remain too fragmented to fill Cryoport’s network efficiently.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
GAAP annual operating loss improved from $121.7 million in FY2024 to $36.8 million in FY2025.
Open source ↗Cryoport must prove that its specialized logistics platform can fund itself from operations rather than relying on balance-sheet cash, financing, or non-operating gains.WeakeningMateriality: Medium
GAAP annual operating cash flow improved from negative $16.3 million in FY2024 to negative $8.6 million in FY2025. A business that cannot convert gross profit into operating cash flow may dilute owners or underinvest just as CGT demand develops.
Watch: Working-capital needs rise with CGT launches faster than customer collections or pricing can offset.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
GAAP annual operating cash flow improved from negative $16.3 million in FY2024 to negative $8.6 million in FY2025.
Open source ↗Cryoport’s balance sheet gives it enough runway to wait for CGT market maturation without forcing value-destructive dilution or distress financing.StrengtheningMateriality: Medium
Cash and cash equivalents increased from $34.1 million at FY2024 year-end to $250.5 million at FY2025 year-end. Runway matters because the business is still operating-loss and operating-cash-flow negative; if cash is consumed before scale arrives, per-share value can be impaired even if the market opportunity is real.
Watch: Management uses the enlarged cash balance for acquisitions or expansion that do not improve utilization or operating cash flow.
Supporting sources
Source notes are factual paraphrases; read the original disclosures below.
Cash and cash equivalents increased from $34.1 million at FY2024 year-end to $250.5 million at FY2025 year-end.
Open source ↗
Full investment case & evidence
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Original research
CGT sponsors and life-sciences customers continue choosing Cryoport for mission-critical temperature-controlled workflows because the cost of a handling failure outweighs the cost of a specialized provider. If Cryoport stays embedded in clinical and commercial therapy logistics, revenue can recover; if customers redesign workflows around other providers or in-house systems, the growth thesis breaks before the income statement fully shows it.
Cryoport’s regulatory, cryogenic, and chain-of-custody requirements give it enough differentiation to avoid pure price competition in life-sciences logistics. If specialization protects pricing, incremental revenue has a chance to create value; if the service is commoditized, revenue growth would be low-quality and margin-dilutive.
Cryoport’s integrated global platform becomes economically attractive only if recovered CGT and life-sciences volume absorbs fixed network, compliance, and personnel costs. The equity upside depends on moving from a specialized service with good gross profit to a business that earns positive operating income; if scale does not arrive, the model remains structurally unprofitable.
Cryoport must prove that its specialized logistics platform can fund itself from operations rather than relying on balance-sheet cash, financing, or non-operating gains. A business that cannot convert gross profit into operating cash flow may dilute owners or underinvest just as CGT demand develops.
Cryoport’s balance sheet gives it enough runway to wait for CGT market maturation without forcing value-destructive dilution or distress financing. Runway matters because the business is still operating-loss and operating-cash-flow negative; if cash is consumed before scale arrives, per-share value can be impaired even if the market opportunity is real.
All standing thesis claims
Original report summary
Cryoport is a leveraged bet that specialized cell-and-gene-therapy cold-chain logistics becomes unavoidable infrastructure and scales faster than fixed network costs and competition commoditize it.
Bull case and bear case
Bull case and bear case for Cryoport
Where the evidence on Cryoport disagrees: Mixed on the latest evidence (Nov 7, 2026). Of its 5 thesis points, 2 strengthening, 2 holding and 1 weakening.
Bull case: what the evidence supports
CGT sponsors and life-sciences customers continue choosing Cryoport for mission-critical temperature-controlled workflows because the cost of a handling failure outweighs the cost of a specialized provider.
Cryoport’s regulatory, cryogenic, and chain-of-custody requirements give it enough differentiation to avoid pure price competition in life-sciences logistics.
Cryoport’s integrated global platform becomes economically attractive only if recovered CGT and life-sciences volume absorbs fixed network, compliance, and personnel costs.
Cryoport’s balance sheet gives it enough runway to wait for CGT market maturation without forcing value-destructive dilution or distress financing.
Bear case: what the evidence questions
Cryoport must prove that its specialized logistics platform can fund itself from operations rather than relying on balance-sheet cash, financing, or non-operating gains.
Thesis-Break Engine
What has broken in Cryoport’s thesis
Each break OptimistFi flagged on Cryoport, dated — with what has historically followed the same kind of break across the market, not a forecast for Cryoport.
- Price target fell below the stockcondition set before this filing
Across all companies, this kind of break has happened 1,809 times before. Those stocks trailed comparable companies by a median of 1% over the next six months, and 33% of them trailed it by 10 points or more.
MARKET + FINANCIAL SNAPSHOT
The numbers behind the thesis
What Changed
- MixedReported results of operations (earnings release).
Cryoport filed an SEC 8-K on 2026-11-05: Reported results of operations (earnings release). It is a dated development that tests the current thesis.
- MixedReported results of operations (earnings release).
Cryoport filed an SEC 8-K on 2026-08-06: Reported results of operations (earnings release). It is a dated development that tests the current thesis.
- MixedReported results of operations (earnings release).
Cryoport filed an SEC 8-K on 2026-05-04: Reported results of operations (earnings release). It is a dated development that tests the current thesis.
Risks / falsifiers
What could break the thesis
- Large CGT sponsors standardize pivotal or commercial distribution with UPS Healthcare, World Courier/Cencora, DHL Life Sciences, or Marken instead of Cryoport.
- UPS Healthcare, DHL, World Courier/Cencora, or Marken match Cryoport’s CGT-specific service quality while undercutting price.
- CGT commercial volumes remain too fragmented to fill Cryoport’s network efficiently.
- Working-capital needs rise with CGT launches faster than customer collections or pricing can offset.
- Management uses the enlarged cash balance for acquisitions or expansion that do not improve utilization or operating cash flow.
CYRX news
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Financial statements
CYRX income statement
Annual filed results · USD · Oldest to newest. Margins are calculated from the reported figures.
CYRX: quick answers
- When does Cryoport (CYRX) report earnings next?
- Cryoport's next results are projected for March 2, 2027, from the dates of its own results filings with the SEC. The company has not confirmed the date. It last reported on November 5, 2026. Earnings calendar
- What is CYRX's short interest?
- As of October 30, 2026, 3.5M CYRX shares were sold short, 6.86% of its shares outstanding, up 37.3% from the count before. At the stock's average daily volume that is 4.1 days to cover. FINRA publishes the count twice a month. CYRX short interest history
- Have members of Congress traded CYRX?
- 20 trades in CYRX have been disclosed under the STOCK Act by members of Congress, the President or senior officials, none in reports made public in the last 90 days. Every disclosed CYRX trade
